Cissus Quadrangularis Powder

The Verdict (Internal Quality Score)

Potency Score: 9.8 / 10. This batch of cissus quadrangularis powder was wild-harvested from rocky, calcium-rich soils in Maharashtra, India (19.7515°N, 75.7139°E). The stem arrives with its full phytochemical profile intact: beta-sitosterol, delta-amyrin, triterpenoids, ascorbic acid, and carotenoids. No extract. No fillers. No binders. The whole stem, dried and ground. We tested this cissus quadrangularis powder for heavy metals, microbials, and potency before releasing it to our Virginia Beach facility. Few cissus supplements on the market can trace their powder to a specific terroir. This one can.

– Back To Your Roots Herbs Research Group

Sensory Analysis

Look: Fine, dark green powder with flecks of pale fiber from the stem. The grind is consistent and free of large particulate.

Smell: Earthy and pungent. A faint bitterness hits the nose first, followed by a green, vegetal undertone. It smells like crushed stems from a living plant.

Taste: Bitter and astringent. The raw powder coats the tongue with a sharp vegetal bite. When mixed into water or fruit juice, the bitterness softens. It is not pleasant on its own, and that is how you know it has not been cut with maltodextrin or rice flour.

How Does Cissus Quadrangularis Powder Support Bone Health?

The Herb: Cissus quadrangularis is a succulent vine from the Vitaceae (grape) family, known across Ayurveda, Siddha, and Unani medicine as veldt grape, hadjod, and asthisamharaka. This herb grows wild in dry, rocky terrain across India and South Africa. The stem is the medicinal part. Back To Your Roots Herbs sources whole cissus quadrangularis stem from growers in Maharashtra and Madhya Pradesh, India (22.9734°N, 78.6569°E), where the plant thrives in calcium-rich alluvial soils.

The Mechanism: Cissus quadrangularis powder acts as an osteoblast stimulator and anti-inflammatory agent. The stem contains ketosterones that accelerate calcification and callus formation during bone healing. Studies confirm that cissus quadrangularis extract increases alkaline phosphatase activity and calcium uptake at fracture sites. The analgesic properties of this herb reduce swelling and pain at the injury location, allowing connective tissue to rebuild faster. This is not a mild effect. In published trials, fracture healing time was reduced by nearly two weeks compared to control groups.

The Evidence: Research by Udupa and Prasad (1964) confirmed that cissus quadrangularis accelerated cortical bone regeneration in clinical settings (PMID: 13923449). A pilot study published in the Nigerian Journal of Surgery (PMC4784127, 2012) found that patients with maxillofacial fractures who received cissus quadrangularis supplements showed faster radiographic healing than the control group. A 2012 study (PMC3343389) pairing cissus quadrangularis with moringa oleifera demonstrated accelerated mandibular fracture recovery. A 2024 systematic review and meta-analysis (PMC12288206) reinforced the positive effects of cissus quadrangularis on bone biomarkers, including osteocalcin and serum calcium.

Cissus Quadrangularis Powder for Joint Pain and Inflammation

Joint pain, stiffness, and swelling are the primary reasons customers reach for cissus quadrangularis supplements. The anti-inflammatory and analgesic compounds in the stem, including flavonoids, triterpenoids, and stilbene derivatives, work to reduce inflammatory markers in joints and connective tissue. This herb has been used in traditional Ayurvedic medicine for centuries to address pain in the bones, joints, and tendons. The pharmacological activity of cissus quadrangularis extends beyond bone healing into broader musculoskeletal support, making it a preferred herbal supplement for active individuals and athletes recovering from injury.

Cissus Quadrangularis and Weight Loss Support

Preliminary research points to the role of cissus quadrangularis in supporting healthy body composition and weight loss. In one clinical trial, participants taking cissus quadrangularis with african mango extract experienced measurable weight loss, dropping 4 kg of body weight over the study period, while the placebo group showed no change. Researchers noted reductions in fasting blood glucose and improvements in metabolic syndrome markers. The mechanism appears to involve serotonin modulation and reduced cortisol activity, both of which influence appetite and fat storage. This is not a fat burner or weight loss drug. This is an adaptogenic herb that supports your body’s natural metabolic pathways when combined with proper diet and exercise.

Cissus Quadrangularis Extract vs. Whole Stem Powder

Many cissus supplements on the market use a standardized cissus quadrangularis extract, often concentrated to a specific percentage of ketosterones. Extracts have their place. They concentrate a single marker compound. But they strip away the full spectrum of supporting compounds: the ascorbic acid, the carotenoids, the calcium oxalate crystals, the flavonoids. Back To Your Roots Herbs chose whole stem powder because the combined action of these compounds matters. Traditional practitioners did not isolate fractions. They ground the whole stem and used it as food and medicine.

Cissus Quadrangularis Benefits for Heart and Cardiovascular Health

Cissus quadrangularis supports the heart and cardiovascular system through its antioxidant activity and ability to modulate lipid profiles. The plant contains resveratrol, ascorbic acid (vitamin C), and other antioxidants that help neutralize free radical damage. Research suggests the herb may support healthy cholesterol levels and reduce oxidative stress, contributing to long-term cardiovascular health. Individuals taking medications for diabetes, blood-thinning drugs, or heart conditions should consult their healthcare provider before adding cissus quadrangularis powder to their supplement regimen.

Cissus Quadrangularis Powder Uses in Ayurveda

In Ayurvedic pharmacology, cissus quadrangularis is classified as a bone-setting herb with warming energy. The plant is used across India to treat fractures, joint pain, digestive discomfort, and menstrual irregularities. In South India, veldt grape powder is prepared as a traditional condiment, blended with herbs and eaten with steamed rice to support bone strength and digestion. The stem, leaves, and roots all find application in traditional medicine, though the stem remains the most studied and most widely used plant part.

Cissus Quadrangularis Dosage and How to Use This Powder

The recommended dosage for cissus quadrangularis powder is 1/2 teaspoon (approximately 1,200 mg) taken once or twice daily. Mix the powder into water, fruit juice, or a smoothie. Some customers put the recommended dose into empty capsules and swallow them to avoid the bitter taste. Start with a smaller dose and increase gradually. The typical recommended daily dosage of cissus quadrangularis extract ranges between 100 and 500 mg, but because this is a whole powder (not a concentrated extract), the dosage is higher to deliver a comparable amount of active compounds.

Who Should Not Take Cissus Quadrangularis? Critical Usage

Contraindications: Pregnant or nursing women should avoid cissus quadrangularis supplements without medical guidance. Individuals taking medications for diabetes (anti-diabetic drugs) or blood-thinning medications should consult a physician. Cissus quadrangularis may interact with these drugs and alter their effects. Known side effects of cissus quadrangularis include headache, gas, diarrhea, and dry mouth. If you experience these side effects, reduce the dose or discontinue use. There is insufficient evidence to confirm safety for children under 18.

Interactions: Cissus quadrangularis may interact with antidiabetes drugs, analgesic medications, and herbal supplements that affect blood clotting. If you take vitamins and supplements alongside prescription medications, consult your healthcare provider before adding this herb. The pharmacological activity of this plant is real, and potential side effects should be taken seriously. Treat this herb with the same caution as any active herbal supplement.

Clinical Specs and Dosage

Comparison: BTYRH Cissus Quadrangularis Powder vs. Generic Cissus Supplements

Disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult a physician before starting any new supplementation regimen. If you take medications for blood sugar management or blood-thinning medications, consult your healthcare provider before use. Written by the Back To Your Roots Herbs Research Group | Fact Checked.